D2 binding above 60% correlates with which outcome?

D2 binding above 60% correlates with which outcome?

• A. Hyperprolactinemia
• B. Efficacy correlation
• C. EPS
• D. Clozapine monitoring

Answer: (B)

D2 receptor occupancy and clinical outcomes: When antipsychotics block dopamine D2 receptors, the amount of receptor occupancy relates to what clinicians observe. A typical therapeutic range is around 60–80% occupancy. Crossing about 60% often aligns with meaningful improvement in psychotic symptoms, showing an efficacy correlation. Going higher tends to raise the risk of extrapyramidal symptoms, and occupancy in the tuberoinfundibular pathway can increase prolactin levels. Clozapine monitoring, by contrast, is about safety monitoring for hematologic issues rather than D2 occupancy. So, D2 binding above 60% most closely mirrors efficacy.

D2 receptor occupancy and clinical outcomes: When antipsychotics block dopamine D2 receptors, the amount of receptor occupancy relates to what clinicians observe. A typical therapeutic range is around 60–80% occupancy. Crossing about 60% often aligns with meaningful improvement in psychotic symptoms, showing an efficacy correlation. Going higher tends to raise the risk of extrapyramidal symptoms, and occupancy in the tuberoinfundibular pathway can increase prolactin levels. Clozapine monitoring, by contrast, is about safety monitoring for hematologic issues rather than D2 occupancy. So, D2 binding above 60% most closely mirrors efficacy.