What is the approximate bioavailability of Brexpiprazole?

What is the approximate bioavailability of Brexpiprazole?

• A. 95%
• B. >99%
• C. 70%
• D. 50%

Answer: (B)

Bioavailability is the fraction of an orally given dose that reaches systemic circulation. Brexpiprazole is reported to have an extremely high oral bioavailability, essentially reaching systemic circulation almost completely. The figure is commonly cited as greater than 99%, meaning nearly all of the ingested drug becomes available to exert its effect. This near-complete absorption reflects efficient uptake from the gut with minimal loss to first-pass metabolism relative to the dose, contributing to predictable plasma concentrations and straightforward dosing. Values like around 95%, 70%, or 50% would indicate more substantial loss during absorption or metabolism, which does not describe brexpiprazole.

Bioavailability is the fraction of an orally given dose that reaches systemic circulation. Brexpiprazole is reported to have an extremely high oral bioavailability, essentially reaching systemic circulation almost completely. The figure is commonly cited as greater than 99%, meaning nearly all of the ingested drug becomes available to exert its effect. This near-complete absorption reflects efficient uptake from the gut with minimal loss to first-pass metabolism relative to the dose, contributing to predictable plasma concentrations and straightforward dosing. Values like around 95%, 70%, or 50% would indicate more substantial loss during absorption or metabolism, which does not describe brexpiprazole.