Which adverse effect is more common with low-potency FGAs and dose-related?

Which adverse effect is more common with low-potency FGAs and dose-related?

• A. Tardive dyskinesia
• B. Anticholinergic Effects
• C. Hyperprolactinemia
• D. Akathisia

Answer: (B)

Low-potency FGAs block multiple receptors, including muscarinic acetylcholine receptors, giving them strong anticholinergic effects. These effects—dry mouth, blurred vision, constipation, urinary retention, and tachycardia—tend to increase as the dose rises, making anticholinergic effects the adverse effect most clearly dose-related with these drugs. Tardive dyskinesia is more about long-term D2 blockade and cumulative exposure, while akathisia and hyperprolactinemia are more strongly linked to the level of D2 antagonism typical of higher-potency agents.

Low-potency FGAs block multiple receptors, including muscarinic acetylcholine receptors, giving them strong anticholinergic effects. These effects—dry mouth, blurred vision, constipation, urinary retention, and tachycardia—tend to increase as the dose rises, making anticholinergic effects the adverse effect most clearly dose-related with these drugs. Tardive dyskinesia is more about long-term D2 blockade and cumulative exposure, while akathisia and hyperprolactinemia are more strongly linked to the level of D2 antagonism typical of higher-potency agents.