Which list correctly represents the metabolizing enzymes/transporters mentioned?

Which list correctly represents the metabolizing enzymes/transporters mentioned?

• A. CYP1A2, CYP2D6, CYP3A4, CYP2C9, CYP2C19, CYP2E1, UGT1A4, P-gp
• B. CYP1A2, CYP2D6, CYP3A4
• C. CYP2B6, CYP2C8
• D. UGT1A4, P-gp only

Answer: (A)

Metabolism of psychotropic meds involves both a broad set of enzymes and a key transporter that together determine how drugs are processed and reach the brain. The best list includes several CYP450 enzymes (CYP1A2, CYP2D6, CYP3A4, as well as CYP2C9, CYP2C19, and CYP2E1), the glucuronosyltransferase UGT1A4, and the efflux transporter P-glycoprotein. This combination covers multiple oxidation pathways (the CYPs), a major phase II conjugation pathway (UGT1A4), and a transporter that can limit absorption and brain exposure (P-gp). The other options miss components: one lists only a subset of CYPs, another lists just two CYPs, and the last lists only UGT1A4 and P-gp without the CYP enzymes.

Metabolism of psychotropic meds involves both a broad set of enzymes and a key transporter that together determine how drugs are processed and reach the brain. The best list includes several CYP450 enzymes (CYP1A2, CYP2D6, CYP3A4, as well as CYP2C9, CYP2C19, and CYP2E1), the glucuronosyltransferase UGT1A4, and the efflux transporter P-glycoprotein. This combination covers multiple oxidation pathways (the CYPs), a major phase II conjugation pathway (UGT1A4), and a transporter that can limit absorption and brain exposure (P-gp).

The other options miss components: one lists only a subset of CYPs, another lists just two CYPs, and the last lists only UGT1A4 and P-gp without the CYP enzymes.