Which statement is true about Brexpiprazole dosing for psychosis according to the monograph?

Which statement is true about Brexpiprazole dosing for psychosis according to the monograph?

• A. 2-4 mg once daily
• B. 6-8 mg once daily
• C. 1-2 mg once daily
• D. 8-12 mg daily

Answer: (A)

For psychosis, brexpiprazole is started at a low daily dose and titrated to a typical target of 2–4 mg, balancing efficacy with tolerability. The medication’s labeling recommends beginning at 1 mg daily for about a week to assess how the patient tolerates it, then increasing to 2 mg, and continuing to adjust up to 4 mg daily as needed. Doses above 4 mg don’t provide additional benefit and increase the risk of adverse effects such as akathisia and weight gain, so they aren’t recommended. Subtherapeutic levels around 1–2 mg may be insufficient for many patients, while 2–4 mg daily aligns with the evidence-based range that the monograph supports for treating psychosis.

For psychosis, brexpiprazole is started at a low daily dose and titrated to a typical target of 2–4 mg, balancing efficacy with tolerability. The medication’s labeling recommends beginning at 1 mg daily for about a week to assess how the patient tolerates it, then increasing to 2 mg, and continuing to adjust up to 4 mg daily as needed. Doses above 4 mg don’t provide additional benefit and increase the risk of adverse effects such as akathisia and weight gain, so they aren’t recommended. Subtherapeutic levels around 1–2 mg may be insufficient for many patients, while 2–4 mg daily aligns with the evidence-based range that the monograph supports for treating psychosis.